Blastic and lytic lesion on bone?

2 yrs ago I had a abnormal bone scan. Blastic lesions where on earth what they were called at that time on the left femur, up the spine, and on the sternum. 2 yrs subsequently repeat bone scan, mroe blastic, lytic lesions on most of the vertebraes, all of the sternum and now the sacrum. Have see 3 oncologists. One suggested pagets disease. Yesterday I had a bone biopsy done. Can anyone tell me the definition for lytic and blastic lesion, or how my lesions could be call this for 2 yrs with no other examination till this new oncologist? Now I linger 5 days for answers. Oncologist said it is not arthritis, blood work doesnt show pagets, and she feels it would not be breast cancer. 31 yr old
Answers:    This must be a really scary and frustrating experience for you! Hopefully the linger will be short and your new doc will be able to spare the time to answer all the question you have.
nnot speak to why the issue has not been diagnosed (or, it sounds, investigated surrounded by depth) until now. There could be a number of reasons why the docs to date believed it be "nothing to worry about." It sounds approaching you've been to a series of different physicians over the years... so it's worthy of note that while it's entirely possible for one doc to "drop the ball," it's pretty unlikely that several docs dropped duplicate ball.

Now... as for lytic vs. blastic lesions...
Bone is tissue. And like adjectives living tissues, it is constantly turning over (old tissue dies/new tissue grows.) This is called "bone remodeling." In bone, there are cells call OSTEOCLASTS that are responsible for breaking down old bone to make room for the new tissue. When osteoclastic leisure is high, LYTIC lesions result. Areas of low bone density.
he flip side, OSTEOBLASTS are responsible for laying down hot bone. When osteoblast activity out-paces the breakdown work of osteoclasts, areas of increased bone density result. These are BLASTIC lesions.

In Paget's disease, this remodeling is out of sync... so some areas of bone are overly dense and others are not dense enough. Typically, Paget's occur in older people. There is a "juvenile" disorder, too, though.

There are other things that could cause lytic + blastic lesions, which will need to be ruled out. Typically we start beside ruling out the more serious pathologies. In this case, differential diagnosis would include metastasis from cancer in another organ. Breast (as you mentioned) and lung will be the first places to look because these both tend met to the bone and they both cause lytic AND blastic lesion. But other organs will have to be ruled out, too. As will primary bone cancers. But there are non-cancerous possibilities, too.

Your oncologist may recommend a PET scan to start. PET scan highlight all areas in your body where on earth "increased metabolism" is going on. It can be a good "whole body" test to flag cancerous tissues anywhere surrounded by the body. (In many countries PET scanning is considered "first line" testing, but surrounded by Canada some docs are still not convinced PET scans are a useful diagnostic tool.)
ver this turns out, it sounds like you hold a good oncologist on the case now. I would urge you to do your best not to nouns. Remember to breathe. Schedule some fun, dynamic events with loved ones to help keep your mind stale things.

And as difficult as it may be, please try to find a way to fit JOY into your routine. Even small things. It sounds trite. And I know some days "joy" is unrealistic/impossible... some days it will take tremendous effort. But whether you own 70 years ahead of you or whether your time is limited, living joyfully helps form the best of the time you have.


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