Difference between sublingual and capsulated nitroglycerin?


Answers:    Sublingual GTN is now most commonly supplied as an aerosol, as the older tablets were enormously unstable and needed to be stored in a cool place. The idea is to supply the nitrate very speedily by allowing it to be absorbed though the mucous membrane of the underside of the tongue,resulting in very fast access to the circulation. It is used for acute episodes of angina and can reach the coronary circulation and begin to increase the blood flow within in the region of 90 seconds. However administered in the way the partially life of the drug is only about 3 minutes!
a range of encapsulated forms of nitrate use various slow release systems to release a trickle of nitrate over long periods, producing ongoing vasodilatation of the coronary circulation for anything up to 16 hours. Source(s): GP for more years than I care to remember
Sublingual, literally 'below the tongue', from Latin, refers to the pharmacological route of administration by which drugs diffuse into the blood through tissues under the tongue. Many pharmaceuticals are designed for sublingual administration, including cardiovascular drugs, steroids, barbiturates, enzymes, and increasingly, vitamins and minerals.
NITROGLYCERIN - SUBLINGUAL
At the first sign of chest torment, sit down and place one tablet under the tongue or between your cheek and gum allowing it to dissolve. The drug is absorbed directly through the lining of the mouth. Do not chew or swallow the tablet. Do not get through, drink or smoke while the nitroglycerin is in your mouth. Relief of symptoms should begin in 1 to 3 minutes. If after 5 minutes in that is no relief of chest pain, use another tablet. If after an additional 5 minutes in that is no relief, use a third tablet. If after another 5 minutes there is no relief, run to a hospital emergency room immediately. To prevent an angina attack, take one tablet 5-10 minutes before happenings that you feel may cause an angina attack, such as exercise or sexual intercourse; or as directed by your doctor. Carry this medication with you at adjectives times.
The buccal extended-release tablets and the extended-release tablets and capsules are usually taken three to six times a day. Do not crush, chew, or divide the extended-release tablets or capsules. Source(s): http://en.wikipedia.org/wiki/Sublingual
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