I have a tolerant on the ventilator who have spurious elevated carboxyhemoglobin level?
Non-smoking 37 year old, with a diagnosis of benign pheochromocytoma which was causative factor for adrenal hemorrhage. The COHb reading within a couple of days was between 3 and 6% . What gives?? I do not twig the source of elevated carboxyhemoglobin?
Answers: Easy peasy lemon squeezy !
eased endogenous production of CO is a feature of any condition with increased heme catabolism. Any group of conditions associated with hemolysis (increased rate of RBC destruction) results within increased heme catabolism and therefore increased production of CO. An additional consideration, in peer reviewed literature in that are a couple of citations that show increased CO (up to 10 to 12%) in some packed red cells for transfusion.
Lets put adjectives this together. Heme catabolism from the "assumed" hematoma that surely formed in this patient would be a source of Hb degradation. And, also assuming that this merciful did receive multiple transfusions.
Severe inflammatory diseases also have shown a very slight increase in endogenous CO production. This is thought to be from the increased expression of heme oxygenase (the enzyme culprit for CO production) induced by inflammatory cytokines. Source(s): RRT-NPS
Related Questions:
Answers: Easy peasy lemon squeezy !
eased endogenous production of CO is a feature of any condition with increased heme catabolism. Any group of conditions associated with hemolysis (increased rate of RBC destruction) results within increased heme catabolism and therefore increased production of CO. An additional consideration, in peer reviewed literature in that are a couple of citations that show increased CO (up to 10 to 12%) in some packed red cells for transfusion.
Lets put adjectives this together. Heme catabolism from the "assumed" hematoma that surely formed in this patient would be a source of Hb degradation. And, also assuming that this merciful did receive multiple transfusions.
Severe inflammatory diseases also have shown a very slight increase in endogenous CO production. This is thought to be from the increased expression of heme oxygenase (the enzyme culprit for CO production) induced by inflammatory cytokines. Source(s): RRT-NPS
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